Randomized controlled trial on the safety of intracameral cephalosporins in cataract surgery

OBJECTIVE To compare the safety profiles of intracameral cephalosporins in cataract surgery. PATIENTS AND METHODS In this controlled trial, 129 patients were randomized to one of four groups to receive 1 mg of one of three cephalosporins - cefazolin, cefuroxime, or ceftazidime, or normal saline - given intracamerally during cataract surgery. Central endothelial cell density (ECD) and retinal center point thickness (CPT) were determined by specular microscopy and ocular coherence tomography, respectively, before and at 3 months after surgery. RESULTS There were no statistical significant differences in the changes of ECD and CPT between eyes receiving intracameral cephalosporin and control. CONCLUSION The use of intracameral cefazolin, cefuroxime, or ceftazidime (1 mg in 0.1-mL solution) at the time of cataract surgery had no significant effect on ECD and CPT postoperatively.